Lectroject Transforms Acyclovir into a Super Anti-viral Herpes Treatment

Acyclovir and Lectroject® Particle Transport Technology:

Until the 1980's there was no known treatment for viruses apart from interferon, lately drugs such as acyclovir [Brand names like Zovirax® (acyclovir), Valtrex® (valacyclovir) and FAMVIR (famciclovir)], have been developed which, while not 100% effective can vary, depending on the method of administration, from 47% to 85% successful.

Electro-cure uses Particle Transport technology. The stream of ions travel along the nerves. Through the apertures in the spine column and into the CSF - The ions carry atoms of medication to travel into deeper cells of the intestines. The ions follow the steam from one electrode to the other through nerve tissue, muscle tissue or mucosal surfaces. The same way as electricity would. The flow of atoms is directly through the body (independent of blood flow) and is able to reach any cell anywhere.

With the Lectroject device Acyclovir is sent into the cells, on the way it is phosphorylated by an enzyme called thymidine kinase, it is then converted to acyclovir diphosphate, following this, it is further phosphorylated by another enzyme guanylate kinase and it enters the cell as acyclovir triphosphate.

This chemical interferes with the viral DNA to prevent replication. In theory this removes the virus. Cells in the body are constantly dying (catabolism) and being replaced (anabolism) i.e. Anabolism and catabolism is known as metabolism. Once the DNA of the virus is interfered with, it cannot affect other cells (the virus is quarantined), and as the old cell is replaced by a new, unaffected cell, the viral particle is removed from the body.

This device works by infiltrating acyclovir into the cell where it neutralizes the virus and destroys it. Although not a "cure-all" acyclovir is a very significant advance in the management of viral diseases. Used through electro-cure the drug becomes a powerful antiviral. Our blind trials carried out at Benmed Park Hospital Clinic showed a mean average of 85%.

Lectroject is far more effective than oral or injected medication as it is not subject to gastric or hepatic degradation.

Iontophoresis (Iontophoretic drug delivery) has been used in the USA for many years and is an accepted form of therapy. If you look up "iontophoresis" and "iontophoretic drug delivery devices" on the internet you'll find that not only Electro-cure but all such machines are effective.

The Electro-cure device is a super-efficient method of transporting antivirals through the skin into the body and by the way it works brings the success rate of acyclovir from 47% to 85%. Lectroject concentrates acyclovir by 50 times. i.e. The device itself doesn't treat the virus, it only sends medication through the skin into the body were its needed to attack all viral DNA present.

The purpose of lectroject, is that it takes an existing drug, Acyclovir, and by changing the way it is delivered into the human body, it is much more efficient and in fact kills the virus 100% (in 85% of the cases) regardless of where it is hiding.



Click to view the lectroject clinical trial results

VIROLOGY

More Information on Acyclovir

The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In vitro, acyclovir triphosphate stops replication of herpes viral DNA.

Through Lectroject this is accomplished in 3 ways:
1) competitive inhibition of viral DNA polymerase,
2) incorporation into and termination of the growing viral DNA chain, and
3) inactivation of the viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the viral TK.



Acyclovir (Zovirax)

Through Lectroject Acyclovir is used to treat herpes virus infections such as oral herpes, genital herpes, shingles, herpes simplex, and chicken pox. Acyclovir interferes with the activity of enzymes needed for the replication of viral DNA in cells. By preventing the multiplication, the herpes virus cannot multiply as easily. The FDA approved the use of acyclovir in 1984. Another option is valacyclovir.

Acyclovir is prescribed as a cream or ointment (topical use), oral tablets, or intravenous liquid to relieve pain, speed recovery, and prevent viral shedding. More recently, acyclovir has been used through lectroject in combination with AZT, to treat AIDS patients.

Availability

Acyclovir is found at a pharmacy in capsules, tablets, liquid, ointment, and doctor or hospitals have acyclovir in injection form.

Effectiveness of Acyclovir for herpes

Multiple studies of the use of acyclovir for the treatment of herpes labialis have suggested that the nominal efficacy of the topical formulation is the result of inadequate penetration of the drug into the target site of infection, the basal epidermis.

Postherpetic neuralgia (PHN) is a complication of shingles (herpes zoster), a painful rash due to varicella-zoster virus reactivation. Studies of patients with PHN and zoster sine herpete (radicular pain without rash) support the notion that low-grade viral ganglionitis contributes to pain. If chronic pain reflects active infection, then antiviral therapy may help patients with PHN. Intravenous acyclovir at a dosage of 10 mg/kg every 8 hours for 14 days followed by oral valacyclovir at a dosage of 1000 mg 3 times per day for 1 month may provide some clinical improvement.

Acyclovir and lectroject

A device that uses "iontophoresis" to enhance tissue penetration of topically applied acyclovir speeds the healing of cold sores. Iontophoresis refers to the use of a small electric current to move ionized substances through the skin into tissues.

Acyclovir and Chickpox

Acyclovir appears to be effective in reducing the number of days with fever and the maximum number of lesions among otherwise healthy children with chickenpox. However, the results of studies have not been overly convincing with respect to the number of days to no new lesions and relief of itchiness. The clinical importance of acyclovir treatment in otherwise healthy children remains uncertain.

Acyclovir Dosage

Oral Acyclovir dosage -- For genital herpes acyclovir dosage : Up to 1,200 mg a day in evenly distributed doses, every four or eight hours taken with food. For shingles acyclovir dosage : Up to 4,000 mg a day in evenly distributed doses every four hours. For chicken pox acyclovir dosage : Up to 800 mg, four times a day, not to exceed 3,200 mg a day. Topical form-- To relieve herpes symptoms acyclovir dosage : Apply a small amount to lesions every three hours (six times a day) for seven days. Use a glove when applying acyclovir ointment.

Acyclovir Side Effects

Acyclovir side effects may be more common in older persons. Common acyclovir side effects include upset stomach, vomiting, diarrhea, dizziness, tiredness, pain, especially in the joints, and changes in vision.

Acyclovir and Pregnancy

Acyclovir has been used by pregnant women and no birth defects or other related problems have been reported; however, studies of acyclovir in pregnancy in humans have been limited and inconclusive.

Breast Feeding

Acyclovir may pass into breast milk. Breast feeding should be avoided while taking any oral form of the drug. No problems are expected with the topical form.

Infants and Children

Acyclovir should not be used for children under two years of age. Its use for children under 12 should be carefully supervised by a physician.

Food Interactions with Acyclovir

No significant food interactions have been reported.

Disease Interactions

Use of acyclovir may cause complications in patients with liver or kidney disease, since these organs work together to remove the medication from the body.