Acyclovir Zovirax iontophoresis

Lectroject Iontophoresis Enhances the Effectiveness of Acyclovir for herpes

Acyclovir Zovirax

Acyclovir is used to treat herpes virus infections such as oral herpes, genital herpes, shingles, herpes simplex, and chicken pox. Acyclovir interferes with the activity of enzymes needed for the replication of viral DNA in cells. By preventing the multiplication, the herpes virus cannot multiply as easily. The FDA approved the use of acyclovir in 1984. Another option is valaciclovir.

More recently, acyclovir has been used in combination with AZT, to treat HIV/AIDS patients.

Bioavailability

Acyclovir (Zovirax), a guanosine analog that inhibits viral DNA synthesis, is the oldest and most-studied medication. It has poor bioavailability and a short half-life, which necessitates frequent dosing. Valacyclovir (Valtrex), a prodrug that metabolizes to acyclovir, has better bioavailability and requires less frequent dosing than acyclovir. Famciclovir (Famvir) is a purine analog that has high bioavailability.

Effectiveness of Acyclovir for herpes

Multiple studies of the use of acyclovir for the treatment of herpes have suggested that the nominal efficacy of the topical formulation is the result of inadequate penetration of the drug into the target site of infection, the basal epidermis. Iontoporesis overcomes bioavailability issues.

Acyclovir and Iontophoresis

Lectroject uses "iontophoresis" to enhance tissue penetration of Acyclovir 5% topical cream, it enters the body via two electrodes. The cream is placed on the electrodes; the electrodes are applied to the inner wrists or in the case of herpes at the top and bottom of the spine to treat the entire body.

The ultimate solution

Lectroject creates a stream of ions. The stream ions travel along the nerves.Through the apertures in the spine column and into the CSF - The ions carry atoms of medication to travel into deeper cells of the intestines. The ions follow the steam from one electrode to the other through nerve tissue, muscle tissue or mucosal surfaces. The same way as electricity would.

The machine works by phosphorylaing acyclovir to acyclovir diphosphate in the presence of thymidine kinase, it next phospholates acyclovir diphosphate to acyclovir triphosphate in the presence of guanylate kinase which act as a virostatic. In other words it controls viruses. Success rate is 85%.

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